Yes, absolutely they are when it come to tuning and timing, especially if it's carby.
You can find the happy medium of tuning for both petrol and LPG, then suddenly the weather in Melbourne changes within half an hour and the vehicle ignition system decided to crap itself and run like crap, either on petrol or LPG.
I've been considering putting a dual curve unit to auto adjust the ignition curve for both fuel types, then with the time and money I spend on it, I might as well spend tad more and put in an EFI dongle from a Skyline or a VL commodore.(Mine is an RB40 with carby). I might still go ahead and install a dual curve ignition adjusting unit. But, till then it will be a PITA to tune the engine to work nicely on both fuels, 'cos I have to constantly fiddle with tuning, be it ignition timing or carby adjustments.
I even think, TB42 carby is much more PITA than RB30 carby. Such a big engine should never have come with a carby.