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You need to make sure that a short circuit at the end of the run is sufficient to trip the breaker. With a 12V supply and a 70A breaker that means a total fault circuit resistance (battery + to battery -) is less than 0.17 ohms (Ohms law R = E/I). It is the resistance that drives what size cable you should use, but bigger is usually better where 12V is concerned. The low value fuses will protect individual circuits (assuming similar principles are applied) but that big breaker needs to protect the main power buss. And it should be as close as possible to the battery.