No harder that putting it just of the floor in the back. Atleast with a slide you can get it on the tray slide, clean it up while its hanging out of the back of the car, then slide the drawer back in. You could even make a double drawer setup, with the top draw for the tyre and another drawer under it that can also come out and act as a table with the top draw still packed away... Lol
If weight is an issue for the tyre on the drawer, some extendable fold out legs would help. Like those twist lock legs that are on the awnings.